Health

New drug shows promise in repairing failing hearts

Agency | December 27, 2016 01:29 PM

New York:A new experimental drug has shown promise in restoring cardiac function after heart failure, according to results of an early human trial.

The researchers found that an infusion of the drug cimaglermin was generally tolerated except for transient nausea and headache.

"These findings support continued clinical development of the investigational drug cimaglermin, including further safety evaluations and detailing the potential improvement on clinical heart failure outcome measures," said lead author of the study Daniel Lenihan from Vanderbilt University in Nashville, Tennessee, US.

Heart failure, characterised by a loss of cardiac function, is among the leading causes of death worldwide.

A significant portion of heart failure patients, particularly those with severe left ventricular systolic dysfunction, do not sufficiently respond to current medical therapy.

Researchers examined the safety and efficacy of a single infusion of cimaglermin, which acts as a growth factor for the heart, helping the structural, metabolic and contractile elements of the heart to repair itself following injury.

The study enrolled 40 heart failure patients who were taking optimal medical therapy for at least three months prior to the trial.

Compared to patients who received a placebo, patients who received a high dose of cimaglermin had a sustained increase in left ventricular ejection fraction, or pumping capacity, through 90 days after dosing, with the maximum increase reached at day 28, according to the study published in the journal JACC: Basic to Translational Science.

The most common side effects were headache and nausea, which were temporarily associated with exposure to the drug.

One patient receiving the highest planned dose of cimaglermin experienced an adverse reaction that met the stopping criteria of US Federal Drug Administration guidance for drug induced liver injury.

"As with all experimental therapeutics, additional studies will be required and subject to regulatory review to determine if the relative risks and benefits of cimaglermin warrant approval," Lenihan noted.

 

Have something to say? Post your comment
Must Read
Punjab Armed Police declares results for the post of BPT-2017  PPA/ Phillaur & Armed Police Cadre ( results attached )
Punjab Armed Police declares results for the post of BPT-2017 PPA/ Phillaur & Armed Police Cadre ( results attached )
Capt Amarinder asks Health Minister to initiate steps to issue show-cause notice to Chintpurni
Capt Amarinder asks Health Minister to initiate steps to issue show-cause notice to Chintpurni
BSF Seizes Two KG heroin in Soft Drink Bottle at Indo-Pak Border
BSF Seizes Two KG heroin in Soft Drink Bottle at Indo-Pak Border
Repeated Police transfers demoralizing police- Phoolka
Repeated Police transfers demoralizing police- Phoolka
Mehbooba Govt bans social network for one month to control ‘social’ unrest in Valley
Mehbooba Govt bans social network for one month to control ‘social’ unrest in Valley
Akali Sarpanch beaten to death, Four Congressmen booked
Akali Sarpanch beaten to death, Four Congressmen booked
Revenue officers to inspect field offices to maintain the decorum
Revenue officers to inspect field offices to maintain the decorum
No need to fuel this anymore: Sonu Nigam on azaan row
No need to fuel this anymore: Sonu Nigam on azaan row
Apple to offer free coding, art classes globally in May
Apple to offer free coding, art classes globally in May
AAP alleges widespread EVM tampering for BJP's civic poll win
AAP alleges widespread EVM tampering for BJP's civic poll win
Apple plans to use micro-LED in 2017 Apple Watch 3
Apple plans to use micro-LED in 2017 Apple Watch 3
AAP trailing, leaders reach Kejriwal's house
AAP trailing, leaders reach Kejriwal's house